Population figures from 500 years ago are necessarily imprecise, but Bergreen estimates that there were about 300,000 inhabitants of Hispaniola in 1492. Between 1494 and 1496, 100,000 died, half due to mass suicide. In 1508, the population was down to 60,000. By 1548, it was estimated to be only 500.
Understandably, some natives fled to the mountains to avoid the Spanish troops, only to have dogs set upon them by Columbus’s men. (Bergreen, 205)